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- Des Moines
- Capital and most populous city of Iowa
- Population and demographics
- State Capitol Building and government
- Des Moines Art Center and cultural attractions
- Greater Des Moines Botanical Garden and outdoor recreation
- Cedar Rapids
- Second-largest city in Iowa
- Location along the Cedar River
- Brucemore Historic Site and cultural heritage
- NewBo City Market and local businesses
- Indian Creek Nature Center and outdoor activities
- Davenport
- Largest of the Quad Cities along the Mississippi River
- Figge Art Museum and cultural institutions
- Davenport Skybridge and riverfront attractions
- Vander Veer Botanical Park and outdoor spaces
- St. Ambrose University and higher education
- Sioux City
- Located at the confluence of the Missouri and Big Sioux Rivers
- Sioux City Public Museum and historical sites
- Orpheum Theatre and performing arts
- Stone State Park and outdoor recreation
- Morningside University and higher education
- Iowa City
- Home to the University of Iowa
- Old Capitol Museum and historical landmarks
- Iowa Avenue Literary Walk and cultural attractions
- Hickory Hill Park and outdoor activities
- Pedestrian Mall and downtown shopping and dining
- Ankeny
- Fast-growing suburb of Des Moines
- Prairie Trail and planned community development
- Ankeny Art Center and cultural events
- High Trestle Trail and outdoor recreation
- Des Moines Area Community College and education
- West Des Moines
- Suburb west of Des Moines
- Jordan Creek Town Center and shopping
- Raccoon River Park and outdoor activities
- Historic Valley Junction and local businesses
- Microsoft and major employers
- Waterloo
- Located along the Cedar River
- Waterloo Center for the Arts and cultural attractions
- Lost Island Water Park and family-friendly activities
- George Wyth State Park and outdoor recreation
- John Deere Tractor & Engine Museum and industrial heritage
- Ames
- Home to Iowa State University
- Reiman Gardens and horticultural attractions
- Main Street Cultural District and local businesses
- Ada Hayden Heritage Park and outdoor activities
- Ames Laboratory and research institutions
- Council Bluffs
- Located along the Missouri River across from Omaha, Nebraska
- Union Pacific Railroad Museum and transportation history
- Harrah’s Council Bluffs and gaming and entertainment
- Lake Manawa State Park and outdoor recreation
- Iowa Western Community College and higher education